Study on the Constituents of Mexican Propolis and Their Cytotoxic Activity against PANC-1 Human Pancreatic Cancer Cells

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• 作者：Feng Li ; Suresh Awale ; Yasuhiro Tezuka ; Hiroyasu Esumi ; Shigetoshi Kadota
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：April 23, 2010
• 年：2010
• 卷：73
• 期：4
• 页码：623-627
• 全文大小：156K
• 年卷期：v.73,no.4(April 23, 2010)
• ISSN：1520-6025

文摘

Three new flavonoids, (2R,3R)-3,5-dihydroxy-7-methoxyflavanone 3-(2-methyl)butyrate (1), (7′′R)-8-[1-(4′-hydroxy-3′-methoxyphenyl)prop-2-en-1-yl]chrysin (2), and (7′′R)-8-[1-(4′-hydroxy-3′-methoxyphenyl)prop-2-en-1-yl]galangin (3), together with 41 known compounds (4−44) were isolated from a methanolic extract of Mexican propolis. Compounds 2 and 3 are unique natural flavones containing a 1-phenylallyl moiety. The in vitro preferential cytotoxicity of all the isolates was evaluated against a PANC-1 human pancreatic cell line. Compound 3 displayed the most potent preferential cytotoxicity (PC₅₀ 4.6 μM) in the nutrient-deprived medium (NDM) and triggered apoptosis-like morphological changes in PANC-1 cells.