Cytotoxic Constituents of Soymida febrifuga from Myanmar

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• 作者：Suresh Awale ; Tatsuya Miyamoto ; Thein Zaw Linn ; Feng Li ; Nwet Nwet Win ; Yasuhiro Tezuka ; Hiroyasu Esumi ; Shigetoshi Kadota
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：September 25, 2009
• 年：2009
• 卷：72
• 期：9
• 页码：1631-1636
• 全文大小：179K
• 年卷期：v.72,no.9(September 25, 2009)
• ISSN：1520-6025

文摘

The 70% ethanol extract of Soymida febrifuga was found to kill PANC-1 human pancreatic cancer cells preferentially under nutrition-deprived conditions at a concentration of 10 μg/mL. Phytochemical investigation led to the isolation of 27 compounds including four new compounds [(3R)-6,4′-dihydroxy-8-methoxyhomoisoflavan (1), (2R)-7,4′-dihydroxy-5-methoxy-8-methylflavan (2), 7-hydroxy-6-methoxy-3-(4′-hydroxybenzyl)coumarin (3), and 6-hydroxy-7-methoxy-3-(4′-hydroxybenzyl)coumarin (4)]. 2′,4′-Dihydroxychalcone (8) displayed the most potent preferential cytotoxicity (PC₅₀ 19.0 μM) against PANC-1 cells. In addition, the cytotoxic activity against colon 26-L5 carcinoma (colon 26-L5), B16-BL6 melanoma (B16-BL6), lung A549 adenocarcinoma (A549), cervix HeLa adenocarcinoma (HeLa), and HT-1080 fibrosarcoma (HT-1080) cell lines and their structure−activity relationship are discussed. The cytotoxic activity of 4′-hydroxy-3,5-dimethoxystilbene (6) against colon 26-L5 (IC₅₀ 2.96 μM) was found to be stronger than the positive control, doxorubicin, at IC₅₀ 3.12 μM.