Iodine-Mediated 伪-Acetoxylation of 2,3-Disubstituted Indoles

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• 作者：Hisaaki Zaimoku ; Takashi Hatta ; Tsuyoshi Taniguchi ; Hiroyuki Ishibashi
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：December 7, 2012
• 年：2012
• 卷：14
• 期：23
• 页码：6088-6091
• 全文大小：270K
• 年卷期：v.14,no.23(December 7, 2012)
• ISSN：1523-7052

文摘

A new method for direct 伪-functionalization of 2,3-disubstituted indoles has been developed. The present reaction provides 伪-acetoxy indole derivatives regioselectively under mild conditions using commercially available and nontoxic iodine reagents. This reaction is a useful synthetic tool because obtained 伪-acetoxy products can be transformed into various functionalized indoles by substitution reactions with nucleophiles.