Syntheses of (卤)-Serratine, (卤)-Lycoposerramine T, and (卤)-Lycopoclavamine B

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• 作者：Hisaaki Zaimoku ; Hiroshi Nishide ; Asami Nishibata ; Naoya Goto ; Tsuyoshi Taniguchi ; Hiroyuki Ishibashi
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：May 3, 2013
• 年：2013
• 卷：15
• 期：9
• 页码：2140-2143
• 全文大小：346K
• 年卷期：v.15,no.9(May 3, 2013)
• ISSN：1523-7052

文摘

The first total syntheses of (卤)-serratine, (卤)-lycoposerramine T, and (卤)-lycopoclavamine B have been accomplished. The functionalized octahydroindane skeleton of these natural products was constructed by an efficient Diels鈥揂lder reaction of an 伪-alkynylcyclopentenone and the stereoselective introduction of a tertiary hydroxyl group. Two of these natural products were divergently synthesized from the same synthetic intermediate at a later stage.