Photocontrol of Spatial Orientation and DNA Cleavage Activity of Copper(II)-Bound Dipeptides Linked by an Azobenzene Derivative

详细信息    查看全文

• 作者：Halan Prakash ; Akemi Shodai ; Hiroyuki Yasui ; Hiromu Sakurai ; Shun Hirota
• 刊名：Inorganic Chemistry
• 出版年：2008
• 出版时间：June 16, 2008
• 年：2008
• 卷：47
• 期：12
• 页码：5045 - 5047
• 全文大小：778K
• 年卷期：v.47,no.12(June 16, 2008)
• ISSN：1520-510X

文摘

Copper(II) ion-bound CysGly dipeptides linked by an azobenzene derivative were photoisomerized between the trans and cis forms. The two copper(II) ion centers were positioned close to each other in the cis form, whereas they were far away from each other in the trans form. The copper complex in the cis form exhibited DNA cleavage activity, whereas the activity in the trans form was negligible. The DNA cleavage activity of the cis form is attributed to the cooperation of the closely located copper(II) centers. The present results show the photocontrol of the cooperation of metal ions for DNA cleavage.