Volume Properties of Decylammonium Chloride and Micelle-Forming Local Anesthetic Mixtures in the Micelle

详细信息    查看全文

• 作者：Hitoshi Matsuki ; Hiroshi Kamaya ; Issaku Ueda ; Michio Yamanaka ; and Shoji Kaneshina
• 刊名：Langmuir
• 出版年：1998
• 出版时间：July 21, 1998
• 年：1998
• 卷：14
• 期：15
• 页码：4030 - 4035
• 全文大小：136K
• 年卷期：v.14,no.15(July 21, 1998)
• ISSN：1520-5827

文摘

The densities of aqueous solutions of a decylammonium chloride (DeAC)-dibucaine hydrochloride (DC·HCl) mixture and a DeAC-tetracaine hydrochloride (TC·HCl) mixture were measured as a function ofthe total molality and composition of the mixture at 298.15 K under atmospheric pressure. The molarvolumes of the mixture in the monomeric and micellar states of both systems were evaluated by applyingthe thermodynamic equations to the apparent molar volumes obtained from the density data. They variedlinearly with composition between the values of pure components. The volume of mixed micelle formationalso showed the linear dependence on the composition. These facts indicate that the DeAC and the anestheticmolecules mix ideally in both the monomeric and micellar states from the viewpoint of volume. On theother hand, the micellar composition was calculated from the composition dependence of the critical micelleconcentration values. The shape of the phase diagram of micelle formation was slightly distorted cigar-type due to the nonideal interaction between DeAC and the anesthetic molecules in the mixed micelle.Ideal mixing of volume in the micellar state indicates that the nonideal interaction is not so strong thatit affects the molar volume of the micelle.