Practical Synthesis of Kainoids: A New Chemical Probe Precursor and a Fluorescent Probe
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- 作者：Shingo Sasaki ; Hiroto Suzuki ; Hitoshi Ouchi ; Tomohiro Asakawa ; Makoto Inai ; Ryuichi Sakai ; Keiko Shimamoto ; Yoshitaka Hamashima ; Toshiyuki Kan
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：January 17, 2014
- 年：2014
- 卷：16
- 期：2
- 页码：564-567
- 全文大小：265K
- ISSN：1523-7052
文摘
A practical total synthesis of kainoid MFPA (5) was achieved in only six steps, via a novel Ni-catalyst-mediated asymmetric conjugate addition reaction. Furthermore, a fluorescein-based fluorescent ionotropic glutamate receptor probe 28 was efficiently synthesized from a precursor derived from a synthetic intermediate of 5.