Tag-Assisted Liquid-Phase Peptide Synthesis Using Hydrophobic Benzyl Alcohols as Supports

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• 作者：Yohei Okada ; Hideaki Suzuki ; Takashi Nakae ; Shuji Fujita ; Hitoshi Abe ; Kazuo Nagano ; Toshihide Yamada ; Nobuyoshi Ebata ; Shokaku Kim ; Kazuhiro Chiba
• 刊名：The Journal of Organic Chemistry
• 出版年：2013
• 出版时间：January 18, 2013
• 年：2013
• 卷：78
• 期：2
• 页码：320-327
• 全文大小：471K
• 年卷期：v.78,no.2(January 18, 2013)
• ISSN：1520-6904

文摘

A soluble tag-assisted liquid-phase peptide synthesis was successfully established based on simple hydrophobic benzyl alcohols, which can be easily prepared from naturally abundant materials. Excellent precipitation yields can be obtained at each step, combining the best properties of solid-phase and liquid-phase techniques. This approach can also be applied efficiently to fragment couplings, allowing chemical synthesis of several bioactive peptides.