Anti-inflammatory Asterosaponins from the Starfish Astropecten monacanthus
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- 作者：Nguyen Phuong Thao ; Nguyen Xuan Cuong ; Bui Thi Thuy Luyen ; Nguyen Van Thanh ; Nguyen Xuan Nhiem ; Young-Sang Koh ; Bui Minh Ly ; Nguyen Hoai Nam ; Phan Van Kiem ; Chau Van Minh ; Young Ho Kim
- 刊名：Journal of Natural Products
- 出版年：2013
- 出版时间：September 27, 2013
- 年：2013
- 卷：76
- 期：9
- 页码：1764-1770
- 全文大小：333K
- 年卷期：v.76,no.9(September 27, 2013)
- ISSN：1520-6025
文摘
Four new asterosaponins, astrosteriosides A鈥揇 (1鈥?b>3 and 5), and two known compounds, psilasteroside (4) and marthasteroside B (6), were isolated from the MeOH extract of the edible Vietnamese starfish Astropecten monacanthus. Their structures were elucidated by chemical and spectroscopic methods including FTICRMS and 1D and 2D NMR experiments. The effects of the extracts and isolated compounds on pro-inflammatory cytokines were evaluated by measuring the production of IL-12 p40, IL-6, and TNF-伪 in LPS-stimulated bone marrow-derived dendritic cells. Compounds 1, 5, and 6 exhibited potent anti-inflammatory activity comparable to that of the positive control. Further studies are required to confirm efficacy in vivo and the mechanism of effects. Such potent anti-inflammatory activities render compounds 1, 5, and 6 important materials for further applications including complementary inflammation remedies and/or functional foods and nutraceuticals.