Advances in the Process Development of Biocatalytic Processes

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• 作者：P盲r Tufvesson ; Joana Lima-Ramos ; Naweed Al Haque ; Krist V. Gernaey ; John M. Woodley
• 刊名：Organic Process Research & Development
• 出版年：2013
• 出版时间：October 18, 2013
• 年：2013
• 卷：17
• 期：10
• 页码：1233-1238
• 全文大小：268K
• 年卷期：v.17,no.10(October 18, 2013)
• ISSN：1520-586X

文摘

Biocatalysis is already established in chemical synthesis on an industrial scale, in particular in the pharmaceutical sector. However, the wider implementation of biocatalysis is currently hindered by the extensive effort required to develop a competitive process. In order that resources spent on development are used in the most efficient manner for these challenging systems, a holistic view on process development and a more in-depth understanding of the underlying constraints (process related as well as biocatalyst related) are required. In this concept article a systematic approach to solve this problem is proposed, involving the use of process tools and methods to assist in development.