Polybrominated Diphenyl Ethers: Structure Determination and Trends in Antibacterial Activity
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- 作者：Hongbing Liu ; Katheryn Lohith ; Margaret Rosario ; Thomas H. Pulliam ; Robert D. O’Connor ; Lori J. Bell ; Carole A. Bewley
- 刊名：Journal of Natural Products
- 出版年：2016
- 出版时间：July 22, 2016
- 年：2016
- 卷：79
- 期：7
- 页码：1872-1876
- 全文大小：293K
- 年卷期：0
- ISSN：1520-6025
文摘
Antibacterial-guided fractionation of the Dictyoceratid sponges Lamellodysidea sp. and two samples of Dysidea granulosa yielded 14 polybrominated, diphenyl ethers including one new methoxy-containing compound (8). Their structures were elucidated by interpretation of spectroscopic data of the natural product and their methoxy derivatives. Most of the compounds showed strong antimicrobial activity with low- to sub-microgram mL–1 minimum inhibitory concentrations against drug-susceptible and drug-resistant strains of Staphylococcus aureus and Enterococcus faecium, and two compounds inhibited Escherichia coli in a structure-dependent manner.