Development of Tartaric Acid Derived Chiral Guanidines and Their Application to Catalytic Enantioselective 伪-Hydroxylation of 尾-Dicarbonyl Compounds

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• 作者：Liwei Zou ; Baomin Wang ; Hongfang Mu ; Huanrui Zhang ; Yuming Song ; Jingping Qu
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：June 21, 2013
• 年：2013
• 卷：15
• 期：12
• 页码：3106-3109
• 全文大小：295K
• 年卷期：v.15,no.12(June 21, 2013)
• ISSN：1523-7052

文摘

A novel library of chiral guanidines featuring a tartaric acid skeleton was developed from diethyl l-tartrate. These guanidines are easily accessed with tunable steric and electronic properties. The utilities of the guanidines were highlighted by their ability to catalyze the 伪-hydroxylation of 尾-ketoesters and 尾-diketones with remarkable efficiency and excellent enantioselectivity.