Rh[III]-Catalyzed Direct C鈥揌 Amination Using N-Chloroamines at Room Temperature

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• 作者：Christoph Grohmann ; Honggen Wang ; Frank Glorius
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：January 20, 2012
• 年：2012
• 卷：14
• 期：2
• 页码：656-659
• 全文大小：332K
• 年卷期：v.14,no.2(January 20, 2012)
• ISSN：1523-7052

文摘

An efficient Rh(III)-catalyzed direct C鈥揌 amination of N-pivaloyloxy benzamides with N-chloroamines proceeding at room temperature was achieved. The versatile directing group allows for selective mono- and diamination and can be readily converted to give valuable benzamide or aminoaniline derivatives. Mechanistic studies have been carried out to elucidate the reaction pathway.