Rh[III]-Catalyzed C鈥揌 Amidation Using Aroyloxycarbamates To Give N-Boc Protected Arylamines

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• 作者：Christoph Grohmann ; Honggen Wang ; Frank Glorius
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：June 21, 2013
• 年：2013
• 卷：15
• 期：12
• 页码：3014-3017
• 全文大小：305K
• 年卷期：v.15,no.12(June 21, 2013)
• ISSN：1523-7052

文摘

The Rh(III)-catalyzed amidation of C(sp²)鈥揌 bonds by the use of electron-deficient aroyloxycarbamates as efficient electrophilic amidation partners is reported. The reaction proceeded under mild conditions with broad functional group tolerance, and pyridine and O-methyl hydroxamic acids serve as efficient directing groups, giving access to valuable N-Boc protected arylamines (also Fmoc and Cbz). Preliminary mechanistic experiments are discussed.