From Indoles to Carbazoles: Tandem Cp*Rh(III)-Catalyzed C鈥揌 Activation/Br酶nsted Acid-Catalyzed Cyclization Reactions

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• 作者：Jia-Qiang Wu ; Zhen Yang ; Shang-Shi Zhang ; Chun-Yong Jiang ; Qingjiang Li ; Zhi-Shu Huang ; Honggen Wang
• 刊名：ACS Catalysis
• 出版年：2015
• 出版时间：November 6, 2015
• 年：2015
• 卷：5
• 期：11
• 页码：6453-6457
• 全文大小：496K
• ISSN：2155-5435

文摘

A tandem Cp*Rh(III)-catalyzed C鈥揌 activation/Br酶nsted acid-catalyzed intramolecular cyclization allows a facile synthesis of carbazoles from readily available indoles. The reaction proceeds under rather mild reaction conditions with the generation of water and N₂ as the only byproducts. Broad substrate scope, excellent functional group tolerance, and high yields were observed. The benzannulation of pyroles for the synthesis of indoles is also feasible using the same protocol.