Cobalt-catalyzed decarboxylative cross-coupling of oxazoles and thiazoles with 伪-oxocarboxylic acids was developed through an sp2 C鈥揌 bond functionalization process. This work represents the first example of cobalt-catalyzed decarboxylative C鈥揌 bond functionalization and provides an efficient means of building some important bioactive heteroaryl ketone derivatives.