Rhodium-Catalyzed Selective Mono- and Diamination of Arenes with Single Directing Site “On Water‿/a>

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• 作者：Md Ashif Ali ; Xiayin Yao ; Guigen Li ; Hongjian Lu
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：March 18, 2016
• 年：2016
• 卷：18
• 期：6
• 页码：1386-1389
• 全文大小：415K
• ISSN：1523-7052

文摘

A Rh(III)-catalyzed selective C–H amination of 2-phenylpyridine derivatives is reported. With pyridine as a directing group, the reaction has high mono- or diamination selectivity, and a wide range of effective substrates, including electron-deficient and -rich aryl azides. Water helps to promote C–H activation, and the concept of a water promoted rollover mechanism is postulated for the diamination step. The reactions were conducted using a Schlenk flask and proceeded smoothly “on water” under atmospheric conditions with nitrogen gas as the only byproduct.