I2-Catalyzed Oxidative Coupling Reactions of Hydrazones and Amines and the Application in the Synthesis of 1,3,5-Trisubstituted 1,2,4-Triazoles

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• 作者：Zhengkai Chen ; Hongli Li ; Weipeng Dong ; Maozhong Miao ; Hongjun Ren
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：March 18, 2016
• 年：2016
• 卷：18
• 期：6
• 页码：1334-1337
• 全文大小：383K
• ISSN：1523-7052

文摘

A general and expeditious approach for the metal-free mediated synthesis of 1,3,5-trisubstituted 1,2,4-triazoles from hydrazones and aliphatic amines has been achieved under aerobic oxidative conditions. The reaction proceeds through a cascade C–H functionalization, double C–N bonds formation, and oxidative aromatization sequence.