Synthesis of Novel Enantiopure Biphenyl P,N-Ligands and Application in Palladium-Catalyzed Asymmetric Addition of Arylboronic Acids to N-Benzylisatin

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• 作者：Hongshan Lai ; Zhiyan Huang ; Qiong Wu ; Yong Qin
• 刊名：Journal of Organic Chemistry
• 出版年：2009
• 出版时间：January 2, 2009
• 年：2009
• 卷：74
• 期：1
• 页码：283-288
• 全文大小：243K
• 年卷期：v.74,no.1(January 2, 2009)
• ISSN：1520-6904

文摘

Enantiopure tetra-ortho-substituted biphenyl phosphinoimine ligands (R_a,S)-3 and (S_a,S)-3 were synthesized via multistep reactions. The first asymmetric addition reactions of arylboronic acids to N-benzylisatin catalyzed by Pd(OAc)₂ and (R_a,S)-3 were studied to provide 3-aryl-3-hydroxyoxindoles in moderate yields and enantioselectivities.