Manganese Dioxide鈥揗ethanesulfonic Acid Promoted Direct Dehydrogenative Alkylation of sp3 C鈥揌 Bonds Adjacent to a Heteroatom

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• 作者：Xigong Liu ; Bin Sun ; Zhiyu Xie ; Xiaojun Qin ; Lei Liu ; Hongxiang Lou
• 刊名：The Journal of Organic Chemistry
• 出版年：2013
• 出版时间：April 5, 2013
• 年：2013
• 卷：78
• 期：7
• 页码：3104-3112
• 全文大小：394K
• 年卷期：v.78,no.7(April 5, 2013)
• ISSN：1520-6904

文摘

A manganese dioxide (MnO₂)鈥搈ethanesulfonic acid (CH₃SO₃H) oxidation system has been developed to efficiently promote direct coupling of benzylic ethers and carbamates with simple ketones via oxidative C鈥揌 bond activation. The alkylation proceeds smoothly under air atmosphere to afford the corresponding products in good to excellent yields (53鈥?7%). The employment of the combination of MnO₂ and CH₃SO₃H is attractive on the basis of economical and environmental issues.