Diterpenoids from the Chinese Liverwort Heteroscyphus tener and Their Antiproliferative Effects
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- 作者：Zhao-Min Lin ; Yan-Xia Guo ; Shu-QI Wang ; Xiao-Ning Wang ; Wen-Qiang Chang ; Jin-Chuan Zhou ; Huiqing Yuan ; Hongxiang Lou
- 刊名：Journal of Natural Products
- 出版年：2014
- 出版时间：June 27, 2014
- 年：2014
- 卷：77
- 期：6
- 页码：1336-1344
- 全文大小：538K
- ISSN：1520-6025
文摘
Four new ent-labdane diterpenoids, heteroscyphins A鈥揇 (1鈥?b>4), and four known diterpenoids (5鈥?b>8) were isolated from the Chinese liverwort Heteroscyphus tener (Steph.) Schiffn. The absolute configuration of compound 1 was defined by single-crystal X-ray diffraction using Cu K伪 radiation. Cytotoxicity tests revealed that compounds 3 and 5 exhibited modest activity against seven cancer cell lines. Compound 5 showed inhibitory effects on prostate cancer (PCa) cell proliferation but with less inhibition on non-neoplastic prostate epithelial cells. Compound 5 markedly caused cell growth arrest at the G0/G1 phase and induced cellular apoptosis through ROS-mediated DNA damage in PCa cells.