Klymollins A鈥揌, Bioactive Eunicellin-Based Diterpenoids from the Formosan Soft Coral Klyxum molle
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- 作者：Fang-Jung Hsu ; Bo-Wei Chen ; Zhi-Hong Wen ; Chiung-Yao Huang ; Chang-Feng Dai ; Jui-Hsin Su ; Yang-Chang Wu ; Jyh-Horng Sheu
- 刊名：Journal of Natural Products
- 出版年：2011
- 出版时间：November 28, 2011
- 年：2011
- 卷：74
- 期：11
- 页码：2467-2471
- 全文大小：270K
- 年卷期：v.74,no.11(November 28, 2011)
- ISSN：1520-6025
文摘
Eight new eunicellin-based diterpenoids, klymollins A鈥揌 (1鈥?b>8), were isolated during the chemical investigation of the soft coral Klyxum molle from Taiwan waters. Their structures were elucidated by extensive spectroscopic analysis. The absolute configuration of 4 was determined by Mosher鈥檚 method. Bioassays of the new metabolites showed that compounds 3鈥?b>8 displayed significant in vitro anti-inflammatory activity by inhibiting the expression of the iNOS protein, and compounds 3, 4, and 6鈥?b>8 also could effectively reduce the accumulation of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.