Hortonones A to C, Hydroazulenones from the Genus Hortonia

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• 作者：Gavin Carr ; David E. Williams ; Rukmal Ratnayake ; Ratnayake Bandara ; Siril Wijesundara ; Tamsin Tarling ; Aruna D. Balgi ; Michel Roberge ; Raymond J. Andersen ; Veranja Karunaratne
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：June 22, 2012
• 年：2012
• 卷：75
• 期：6
• 页码：1189-1191
• 全文大小：168K
• 年卷期：v.75,no.6(June 22, 2012)
• ISSN：1520-6025

文摘

The new hexahydroazulenones hortonones A (1) to C (3) were isolated from the leaves of three representative species of the endemic Sri Lankan genus Hortonia that belongs to the family Monimiaceae. Hortonones A (1) and B (2) have the unprecedented rearranged hortonane sesquiterpenoid carbon skeleton, and hortonone C (3) has the unprecedented rearranged and degraded 13-norhortonane skeleton. Hortonone C (3) exhibited in vitro cytotoxicity against human breast cancer MCF-7 cells at 5 渭g/mL.