Quercetin and Ferulic Acid Aggravate Renal Carcinoma in Long-Term Diabetic Victims
详细信息 查看全文
- 作者：Chiu-Lan Hsieh ; Chiung-chi Peng ; Yu-Ming Cheng ; Li-Yun Lin ; Yaw-Bee Ker ; Chi-Huang Chang ; Kuan-Chou Chen ; Robert Y. Peng
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2010
- 出版时间：August 25, 2010
- 年：2010
- 卷：58
- 期：16
- 页码：9273-9280
- 全文大小：1127K
- 年卷期：v.58,no.16(August 25, 2010)
- ISSN：1520-5118
文摘
Many phytoantioxidants have therapeutic drawbacks due to their potent prooxidant bioactivity. It is hypothesized that phytoantioxidants (PAO) are beneficial only to the early-stage diabetes mellitus (DM) and will become ineffective once renopathy occurs. Gallic acid, rutin, EGCG, ferulic acid (FA), and quercetin were tried on the streptozotocin (STZ)-induced DM rat model for a 28 week experimental period. All of these PAO were shown to be ineffective for hypoglycemic action. The incidence of cataract (50%), injured glomerules, and renal cell carcinoma (RCC) was very common, among which the most severely affected involved the quercetin- and the FA-treated groups. The tumorigenicity of ferulic acid is still unclear. However, for quercetin, this can be attributted to (i) the prooxidant effect, (ii) the insulin−secretagogue bioactivity, and (iii) the competitive and noncompetitive inhibition on the O-methyltransferase to enhance the estradiol-induced tumorigenesis. Conclusively, quercetin and FA are able to aggravate, if not induce, nephrocarcinoma. It is time to reevaluate the tumorigenic detrimental effect of PAO, especially those exhibiting prooxidant bioactivity.