Cytotoxic Sesquiterpene Lactones from Pseudoelephantopus spicatus
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- 作者：Yu-Liang Yang ; Sue-Ming Chang ; Ching-Chung Wu ; Pei-Wen Hsieh ; Shu-Li Chen ; Fang-Rong Chang ; Wen-Chun Hung ; Hamad H. Issa ; Yang-Chang Wu
- 刊名：Journal of Natural Products
- 出版年：2007
- 出版时间：November 2007
- 年：2007
- 卷：70
- 期：11
- 页码：1761 - 1765
- 全文大小：256K
- 年卷期：v.70,no.11(November 2007)
- ISSN：1520-6025
文摘
Five new sesquiterpene lactones, spicatolides D−H (1−5), along with four known compounds, pitocarphin D (6), 8α-acetoxy-10α-hydroxy-13-O-methylhirsutinolide (7), spicatolide A (8), and 13-O-methylvernojalcanolide 8-O-acetate (9), were isolated from an ethyl acetate extract of the aerial parts of Pseudoelephantopus spicatus. The structures of the new compounds were elucidated on the basis of spectroscopic data interpretation. All of the compounds isolated were evaluated for their cytotoxic effects against five human cancer cell lines. Compounds 1, 3, and 4 showed cytotoxicity (IC50 < 5 µ g/mL) against the Hep3B and MCF-7 cancer cell lines.