Antihyperglycemic Effect of Syringaldehyde in Streptozotocin-Induced Diabetic Rats
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- 作者：Chia-Hsin Huang ; Mei-Fen Chen ; Hsien-Hui Chung ; Juei-Tang Cheng
- 刊名：Journal of Natural Products
- 出版年：2012
- 出版时间：August 24, 2012
- 年：2012
- 卷：75
- 期：8
- 页码：1465-1468
- 全文大小：198K
- 年卷期：v.75,no.8(August 24, 2012)
- ISSN：1520-6025
文摘
The antihyperglycemic effect of syringaldehyde (1), purified from the stems of Hibiscus taiwanensis, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats) showing type-1 like diabetes mellitus. Bolus intravenous injection of 1 showed antihyperglycemic activity in a dose-dependent manner in STZ-diabetic rats. An effective dose of 7.2 mg/kg of 1 attenuated significantly the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. A glucose uptake test showed that 1 exhibits an increase of glucose uptake activity in a concentration-related manner. Moreover, an effect by 1 was shown for insulin sensitivity in STZ-diabetic rats. The compound was found to increase insulin sensitivity in STZ-diabetic rats. These results suggest that syringaldehyde (1) can increase glucose utilization and insulin sensitivity to lower plasma glucose in diabetic rats.