Trojan-Horse Nanotube On-Command Intracellular Drug Delivery
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- 作者：Chia-Hsuan Wu ; Cong Cao ; Jin Ho Kim ; Chih-Hsun Hsu ; Harold J. Wanebo ; Wayne D. Bowen ; Jimmy Xu ; John Marshall
- 刊名：Nano Letters
- 出版年：2012
- 出版时间：November 14, 2012
- 年：2012
- 卷：12
- 期：11
- 页码：5475-5480
- 全文大小：370K
- 年卷期：v.12,no.11(November 14, 2012)
- ISSN：1530-6992
文摘
A major challenge to nanomaterial-based medicine is the ability to release drugs on-command. Here, we describe an innovative drug delivery system based on carbon nanotubes (CNTs), in which compounds can be released inside cells from within the nanotube 鈥渙n-command鈥?by inductive heating with an external alternating current or pulsed magnetic field. Without inductive heating the drug remains safely inside the CNTs, showing no toxicity in cell viability tests. Similar to the 鈥淭rojan-Horse鈥?in function, we demonstrate the delivery of a combination of chemotherapeutic agents with low aqueous solubility, paclitaxel (Taxol), and C6-ceramide, to multidrug resistant pancreatic cancer cells. Nanotube encapsulation permitted the drugs to be used at a 100-fold lower concentration compared to exogenous treatment yet achieve a comparable 70% cancer kill rate.