Micronization of p-Aminosalicylic Acid Particles Using High-Gravity Technique

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• 作者：Yu-Shao Chen ; Yao-Hsuan Wang ; Hwai-Shen Liu ; Kuang-Yang Hsu ; Clifford Y. Tai
• 刊名：Industrial & Engineering Chemistry Research
• 出版年：2010
• 出版时间：September 15, 2010
• 年：2010
• 卷：49
• 期：18
• 页码：8832-8840
• 全文大小：756K
• 年卷期：v.49,no.18(September 15, 2010)
• ISSN：1520-5045

文摘

An antisolvent precipitation process was adopted in this study to prepare micrometer-sized p-aminosalicylic acid (PAS) particles using the high-gravity technique. The effects of operating variables on the particle size were investigated. With an increase in the dispersant concentration and disk diameter or a decrease in the drug (PAS) concentration, the particle size of PAS was reduced. In addition, a circular-tube distributor was more effective than a straight-tube distributor for micronization. On the other hand, the effect of the liquid flow rate in the range between 0.25 and 1 L/min was less significant. The high-pressure homogenization following the high-gravity precipitation would effectively reduce the agglomeration of the particles in the suspension to produce drug particles with a mean size of 1 μm. The enhancement of the dissolution rate was significant for the micronized drug particles. The results indicate that the high-gravity process is a promising approach for micronizing drug particles.