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• 作者：Koushik Das Sarma ; Ji Zhang ; Timothy T. Curran
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：April 27, 2007
• 年：2007
• 卷：72
• 期：9
• 页码：3311 - 3318
• 全文大小：214K
• 年卷期：v.72,no.9(April 27, 2007)
• ISSN：1520-6904

文摘

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Novel 5-(1'-hydroxy)--butyrolactone and -butyrolactam subunits were synthesized by direct vinylogousaldol addition of ,-dichloro -butyrolactones and -butyrolactams with aldehydes under basic conditions.Different bases and solvents were screened in the context of generating -butyrolactones. Diastereoselectivity was observed and -butenolides and -butyrolactams showed opposite diastereoselectivityunder the same reaction condition.