Calcium-Catalyzed Diastereo- and Enantioselective 1,4-Addition of Glycine Derivatives to ,<img src="http://pubs.acs.org/images/gifch

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• 作者：Sh<img src="http ; //pubs.acs.org/images/entities/umacr.gif" border="0"> Kobayashi ; Tetsu Tsubogo ; Susumu Saito ; Yasuhiro Yamashita
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：March 6, 2008
• 年：2008
• 卷：10
• 期：5
• 页码：807 - 809
• 全文大小：60K
• 年卷期：v.10,no.5(March 6, 2008)
• ISSN：1523-7052

文摘

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The first highly diastereo- and enantioselective catalytic asymmetric 1,4-addition reactions of a glycine Schiff base to -substituted ,-unsaturated esters have been developed. The reaction pathway was successfully controlled, and the desired 1,4-addition products were exclusivelyobtained with high enantioselectivities. The product obtained was converted to a 3-substituted glutamic acid derivative by acid hydrolysis.