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The first highly diastereo- and enantioselective catalytic asymmetric 1,4-addition reactions of a glycine Schiff base to
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-substituted
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,
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-unsaturated esters have been developed. The reaction pathway was successfully controlled, and the desired 1,4-addition products were exclusivelyobtained with high enantioselectivities. The product obtained was converted to a 3-substituted glutamic acid derivative by acid hydrolysis.