Limonoids and Triterpenoids as 11β-HSD1 Inhibitors from Walsura robusta

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• 作者：Guo-Cai Wang ; Jin-Hai Yu ; Yu Shen ; Ying Leng ; Hua Zhang ; Jian-Min Yue
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：April 22, 2016
• 年：2016
• 卷：79
• 期：4
• 页码：899-906
• 全文大小：407K
• 年卷期：0
• ISSN：1520-6025

文摘

Nine new cedrelone-type limonoid derivatives, walsunoids A–I (1–9), and 11 known compounds were isolated from the leaves of Walsura robusta. Walsunoid A (1) is a new degradation product of cedrelone-type limonoids, and walsunoid I (9) is a rare cedrelone-type limonoid amide. Their structures and absolute configurations were determined by spectroscopic data, single-crystal X-ray diffraction, and ECD data analyses. Five compounds showed moderate inhibitory activities against human and/or mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with IC₅₀ values ranging from 0.69 to 9.9 μM.