A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights
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- 作者：Wei Gao ; Matthew L. Hillwig ; Luqi Huang ; Guanghong Cui ; Xueyong Wang ; Jianqiang Kong ; Bin Yang ; Reuben J. Peters
- 刊名：Organic Letters
- 出版年：2009
- 出版时间：November 19, 2009
- 年：2009
- 卷：11
- 期：22
- 页码：5170-5173
- 全文大小：151K
- 年卷期：v.11,no.22(November 19, 2009)
- ISSN：1523-7052
文摘
Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza Bunge. The initial results from a functional genomics-based investigation of tanshinone biosynthesis, specifically the functional identification of the relevant diterpene synthases from S. miltiorrhiza, are reported. The cyclohexa-1,4-diene arrangement of the distal ring poises the resulting miltiradiene for the ensuing aromatization and hydroxylation to ferruginol suggested for tanshinone biosynthesis.