Aqueous Compatible Fullerene−Doxorubicin Conjugates

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• 作者：Fushen Lu ; Sk. Anwarul Haque ; Sheng-Tao Yang ; Pengju G. Luo ; Lingrong Gu ; Alex Kitaygorodskiy ; Huaping Li ; Sebastian Lacher ; Ya-Ping Sun
• 刊名：Journal of Physical Chemistry C
• 出版年：2009
• 出版时间：October 15, 2009
• 年：2009
• 卷：113
• 期：41
• 页码：17768-17773
• 全文大小：181K
• 年卷期：v.113,no.41(October 15, 2009)
• ISSN：1932-7455

文摘

Covalent conjugates of fullerene C₆₀ and the highly effective anticancer drug doxorubicin (DOX) were prepared and studied. The conjugation was through the amide linkage to preserve the intrinsic properties of DOX and fullerene cage. As designed, the conjugates with hydrophilic ethylene glycol spacers exhibited much improved aqueous compatibility, with significant solubility in water−DMSO mixtures. The antineoplastic activities of DOX were apparently unaffected in the conjugates according to evaluations in vitro with a human breast cancer cell line.