Dual-Functional Gadolinium-Based Copper(II) Probe for Selective Magnetic Resonance Imaging and Fluorescence Sensing

详细信息    查看全文

• 作者：Xiaolin Zhang ; Xu Jing ; Tao Liu ; Gang Han ; Huaqiang Li ; Chunying Duan
• 刊名：Inorganic Chemistry
• 出版年：2012
• 出版时间：February 20, 2012
• 年：2012
• 卷：51
• 期：4
• 页码：2325-2331
• 全文大小：385K
• 年卷期：v.51,no.4(February 20, 2012)
• ISSN：1520-510X

文摘

A unique gadolinium complex, Nap-DO3A-Gd, comprising a naphthylamine luminescent moiety, a di-2-picolylamine (DPA) binding chelator, and a 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A) moiety has been designed and synthesized as a dual-functional probe for selective magnetic resonance imaging and fluorescent sensing of copper(II) in living cells. Nap-DO3A-Gd exhibited a turn-on manner of relaxivity changes and a fluorescent quenching toward Cu²⁺. Through the introduction of naphthalamide into the Gd³⁺ contrast agent platform to restrict the coordination ability of the DPA chelator and with Gd³⁺ coordinating to the DPA moiety to turn away the interferences of other metal cations from Cu²⁺ detection, the probe featured selective relaxivity changes toward Cu²⁺ over other metal ions and brought unique Cu²⁺-specific luminescent responses. The probe was water-soluble with the luminescent detection limit established at 6 ppb and was successfully used for luminescence imaging detection of copper(II) in living cells. The results demonstrated the efficiency and advantage of our approach in the development of a dual-modality image.