文摘
Recently, we reported that amine-induced folding of a more fluorescent, more linear structure into less fluorescent, more curved or helically folded states enables patterned recognitions of amines and ammoniums. In this article, we have carried out extensive ab initio calculations at the B3LYP/6-31G level that not only map out the detailed amine-induced folding/quenching pathways and plausible folding/quenching species but also surprisingly reveal the binding of amines to anionic hosts to be unusually cooperative in a way that the progressively more charged anionic hosts act as increasingly better 鈥渁mine trappers鈥? Accordingly amine-dependent folding occurs via a synergistic action of amines鈥?basicity and the progressively more curved backbone of the host. Although a hexamer carrying four deprotonable hydroxyl sites can reach a tetra-anionic state, mono-, di-, tri-, and tetra-anionic complexes likely dominate as the major quenching species in the presence of, respectively, 2, 4, 8, and 72 equiv of primary amines.