Proton Gradient-Induced Water Transport Mediated by Water Wires Inside Narrow Aquapores of Aquafoldamer Molecules

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• 作者：Huaiqing Zhao ; Shen Sheng ; Yunhan Hong ; Huaqiang Zeng
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：October 8, 2014
• 年：2014
• 卷：136
• 期：40
• 页码：14270-14276
• 全文大小：530K
• ISSN：1520-5126

文摘

Hollow tubular aquapores inside aquafoldamers can be created via the 鈥渟ticky鈥?end-mediated formation of 1D chiral helical stacks involving same-handed helices, and are capable of aligning H-bonded water molecules in a chain-like fashion. These aquapores uniquely feature a small cavity of 鈭?.8 脜 in diameter, a size identical to that of the water molecule and also comparable to the narrowest opening in naturally occurring aquaporins measuring 鈭? 脜 across, and hence allow not only proton transport but also unique proton-gradient-induced water transport across the lipid membranes in the presence of proton gradient.