Insulin Secretagogue Bioactivity of Finger Citron Fruit (Citrus medica L. var. Sarcodactylis Hort, Rutaceae)

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• 作者：Chiung-Huei Peng ; Yaw-Bee Ker ; Ching-Feng Weng ; Chiung-Chi Peng ; Chien-Ning Huang ; Li-Yun Lin ; Robert Y. Peng
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2009
• 出版时间：October 14, 2009
• 年：2009
• 卷：57
• 期：19
• 页码：8812-8819
• 全文大小：891K
• 年卷期：v.57,no.19(October 14, 2009)
• ISSN：1520-5118

文摘

Finger citron [Citrus medica L. var. Sarcodactylis Hort, Rutaceae] (FC) fruits, widely cultivated in Japan, the southern provinces of China and Taiwan, are commonly used as functional vegetables and preserved as sweetmeats. Previously we identified the major compounds in essential oils (% in EO) of FC fruits to be d-limonene (51.24), γ-terpenene (33.71), α-pinene (3.40), and β-pinene (2.88). Documented evidence on its insulin secretion characteristics is still lacking. In parallel to compositional analysis, we performed in vivo the safety, hypoglycemic, and antidiabetic tests in Sprague-Dawley−SPF rats and Wistar DIO rats respectively. By kinetic analysis on the hypoglycemic patterns of the intraperitoneal glucose tolerance (IPGTT) and the insulin−glucose tolerance tests (IGTT), its insulin secretagogue effect was confirmed. In conclusion, FC fruits that concomitantly possess insulin secretagogue and slimming effects would be very beneficial to type 2 diabetes mellitus patients.