Antileishmaniasis Activity of Flavonoids from Consolida oliveriana
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- 作者：Clotilde Marn ; Samira Boutaleb-Charki ; Jess G. Daz ; Oscar Huertas ; Mara J. Rosales ; Gregorio Prez-Cordon ; Ramon Guitierrez-Snchez ; Manuel Snchez-Moreno
- 刊名：Journal of Natural Products
- 出版年：2009
- 出版时间：June 26, 2009
- 年：2009
- 卷：72
- 期：6
- 页码：1069-1074
- 全文大小：235K
- 年卷期：v.72,no.6(June 26, 2009)
- ISSN：1520-6025
文摘
A set of flavonoids from Consolida oliveriana, kaempferol (1), quercetin (2), trifolin (3), and acetyl hyperoside (5) and their O-acetyl derivatives (1a, 2a, 3a), and octa-O-acetylhyperoside (4) showed leishmanicidal activity against promastigote as well as amastigote forms of Leishmania spp. The cellular proliferation, metabolic, and ultrastructural studies showed that the acetylated compounds 2a, 3a, and 4 were highly active against Leishmania (V.) peruviana, while 2a as well as 4 were effective against Leishmania (V.) braziliensis. These compounds were not cytotoxic and are effective at similar concentrations up to or lower than the reference drugs (pentostam and glucantim).