Layer-by-Layer Self-Assembly of Multilayer Zirconia Nanoparticles on Silica Spheres for HPLC Packings

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• 作者：Huijuan Dun ; Weiqiang Zhang ; Yu Wei ; Song Xiuqing ; Yongmin Li ; and Liren Chen
• 刊名：Analytical Chemistry
• 出版年：2004
• 出版时间：September 1, 2004
• 年：2004
• 卷：76
• 期：17
• 页码：5016 - 5023
• 全文大小：168K
• 年卷期：v.76,no.17(September 1, 2004)
• ISSN：1520-6882

文摘

A novel zirconia-based HPLC packing material, ZrO₂/SiO₂, which consists of micrometer-sized silica spheresas core and nanometer-sized zirconia particles as surfacecoating, was prepared by a layer-by-layer self-assemblytechnique. The material exhibits favorable characteristicsfor HPLC applications, including high surface area andpore volume, good pore structure, narrow particle size,and pore size distribution. Not only the support ZrO₂/SiO₂ but also the stationary-phase C₁₈ bonded ZrO₂/SiO₂exhibits excellent chemical stability. In addition, goodpermeability was observed for both of them. High specificarea surface and good permeability of ZrO₂/SiO₂ permita high loading amount of chiral polymer on it and greatlyimproved the enantioselectivity and resolution for somechiral separations.