Effect of Supercritical Fluids on C11-Hydroxylation Activity of Absidia coerulea
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- 作者：Baoquan Zhang ; Huiming Zhu ; and Xiufeng Liu
- 刊名：Biotechnology Progress
- 出版年：2004
- 出版时间：December 2004
- 年：2004
- 卷：20
- 期：6
- 页码：1885 - 1887
- 全文大小：109K
- 年卷期：v.20,no.6(December 2004)
- ISSN：1520-6033
文摘
The viability and C11
-hydroxylation activity of Absidia coerulea were measured aftertreatment with compressed or supercritical CO2 and C2H4 under various initial pHand temperature conditions. The specific activity of A. coerulea on C11-hydroxylationcan reach 23% and 75%, respectively, after treatment with 7.5 MPa of CO2 and C2H4,leading to the feasibility of enhancing both the solubility of the reactants and the-hydrocortisone yield for the hydroxylation of Reichsterin's substance acetate by usingsupercritical C2H4 as an alternative to the organic solvent.
-hydroxylation activity of Absidia coerulea were measured aftertreatment with compressed or supercritical CO2 and C2H4 under various initial pHand temperature conditions. The specific activity of A. coerulea on C11-hydroxylationcan reach 23% and 75%, respectively, after treatment with 7.5 MPa of CO2 and C2H4,leading to the feasibility of enhancing both the solubility of the reactants and the-hydrocortisone yield for the hydroxylation of Reichsterin's substance acetate by usingsupercritical C2H4 as an alternative to the organic solvent.