Photo-induced Metal-Catalyst-Free Aromatic Finkelstein Reaction

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• 作者：Lu Li ; Wenbo Liu ; Huiying Zeng ; Xiaoyue Mu ; Gonzalo Cosa ; Zetian Mi ; Chao-Jun Li
• 刊名：Journal of the American Chemical Society
• 出版年：2015
• 出版时间：July 8, 2015
• 年：2015
• 卷：137
• 期：26
• 页码：8328-8331
• 全文大小：295K
• ISSN：1520-5126

文摘

The facile iodination of aromatic compounds under mild conditions is a great challenge for both organic and medicinal chemistry. Particularly, the synthesis of functionalized aryl iodides by light has long been considered impossible due to their photo-lability, which actually makes aryl iodides popular starting materials in many photo-substitution reactions. Herein, a photo-induced halogen exchange in aryl or vinyl halides has been discovered for the first time. A broad scope of aryl iodides can be prepared in high yields at room temperature under exceptionally mild conditions without any metal or photo-redox catalysts. The presence of a catalytic amount of elemental iodine could promote the reaction significantly.