Tetrachlorocarbonyliridates: Water-Soluble Carbon Monoxide Releasing Molecules Rate-Modulated by the Sixth Ligand

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• 作者：Damian E. Bikiel ; Estefani虂a Gonza虂lez Solveyra ; Florencia Di Salvo ; Humberto M. S. Milagre ; Marcos N. Eberlin ; Rodrigo S. Corre虃a ; Javier Ellena ; Dari虂o A. Estrin ; Fabio Doctorovich
• 刊名：Inorganic Chemistry
• 出版年：2011
• 出版时间：March 21, 2011
• 年：2011
• 卷：50
• 期：6
• 页码：2334-2345
• 全文大小：1102K
• 年卷期：v.50,no.6(March 21, 2011)
• ISSN：1520-510X

文摘

A new family of compounds is presented as potential carbon monoxide releasing molecules (CORMs). These compounds, based on tetrachlorocarbonyliridate(III) derivatives, were synthesized and fully characterized by X-ray diffraction, electrospray mass spectrometry, IR, NMR, and density functional theory calculations. The rate of CO release was studied via the myoglobin assay. The results showed that the rate depends on the nature of the sixth ligand, trans to CO, and that a significant modulation on the release rate can be produced by changing the ligand. The reported compounds are soluble in aqueous media, and the rates of CO release are comparable with those for known CORMs, releasing CO at a rate of 0.03鈭?.58 渭M min<sup>鈭?sup> in a 10 渭M solution of myoglobin and 10 渭M of the complexes.