Approach to the Synthesis of Cladiell-11-ene-3,6,7-triol

详细信息    查看全文

• 作者：John M. Hutchison ; Harriet A. Lindsay ; Silvana S. Dormi ; Gavin D. Jones ; David A. Vicic ; Matthias C. McIntosh
• 刊名：Organic Letters
• 出版年：2006
• 出版时间：August 17, 2006
• 年：2006
• 卷：8
• 期：17
• 页码：3663 - 3665
• 全文大小：64K
• 年卷期：v.8,no.17(August 17, 2006)
• ISSN：1523-7052

文摘

LE>l061072jn00001>ls/orlef7/8/i17/figures/ol061072jn00001.gif" ALIGN="left" HSPACE=5>The synthesis of an advanced intermediate in the synthesis of the title compound has been achieved. Key steps include an Ireland-Claisenrearrangement to install the C7 tertiary alcohol stereocenter, an S_N2' reaction of an alkoxymethyl Cu reagent, and a diastereoselective Re-catalyzed allylic alcohol transposition.