neo-Clerodane Diterpenoids from Scutellaria barbata and Their Inhibitory Effects on LPS-Induced Nitric Oxide Production

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• 作者：Eung Tae Yeon ; Jin Woo Lee ; Chul Lee ; Qinghao Jin ; Hari Jang ; Dongho Lee ; Jong Seog Ahn ; Jin Tae Hong ; Youngsoo Kim ; Mi Kyeong Lee ; Bang Yeon Hwang
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：September 25, 2015
• 年：2015
• 卷：78
• 期：9
• 页码：2292-2296
• 全文大小：286K
• ISSN：1520-6025

文摘

Three new neo-clerodane diterpenoids (1鈥?b>3) along with 12 known compounds (4鈥?b>15) were isolated from a methanol extract of the aerial parts of Scutellaria barbata. The structures of 1鈥?b>3 were determined by interpretation of their 1D and 2D NMR spectroscopic data as well as HRESIMS values. All isolated compounds were tested for their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Compounds 1鈥?b>4, 7, and 10鈥?b>12 were found to inhibit nitric oxide production with IC₅₀ values ranging from 20.2 to 35.6 渭M.