Amination of Heterocyclic Compounds with O-Benzoylhydroxylamine Derivatives

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• 作者：Luca Parlanti ; Robert P. Discordia ; John Hynes ; Jr. ; Michael M. Miller ; Harold R. O'Grady ; Zhongping Shi
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：September 13, 2007
• 年：2007
• 卷：9
• 期：19
• 页码：3821 - 3824
• 全文大小：123K
• 年卷期：v.9,no.19(September 13, 2007)
• ISSN：1523-7052

文摘

The N-amination of heterocyclic compounds 1a-k with O-benzoylhydroxylamine derivatives 5 was developed and demonstrated to be a superioralternative to existing N-amination methods. A structure-reactivity relationship study was performed on variously substituted O-benzoylhydroxylamine derivatives, leading to the discovery of the novel and more efficient aminating reagents 5h and 5i.