Self-Healing Elastin–Bioglass Hydrogels
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- 作者：Qiongyu Zeng ; Malav S. Desai ; Hyo-Eon Jin ; Ju Hun Lee ; Jiang Chang ; Seung-Wuk Lee
- 刊名：Biomacromolecules
- 出版年：2016
- 出版时间：August 8, 2016
- 年：2016
- 卷：17
- 期：8
- 页码：2619-2625
- 全文大小：482K
- 年卷期：0
- ISSN：1526-4602
文摘
Tailorable hydrogels that are mechanically robust, injectable, and self-healable, are useful for many biomedical applications including tissue repair and drug delivery. Here we use biological and chemical engineering approaches to develop a novel in situ forming organic/inorganic composite hydrogel with dynamic aldimine cross-links using elastin-like polypeptides (ELP) and bioglass (BG). The resulting ELP/BG biocomposites exhibit tunable gelling behavior and mechanical characteristics in a composition and concentration dependent manner. We also demonstrate self-healing in the ELP/BG hydrogels by successfully reattaching severed pieces as well as through rheology. In addition, we show the strength of genetic engineering to easily customize ELP by fusing cell-stimulating “RGD” peptide motifs. We showed that the resulting composite materials are cytocompatible as they support the cellular growth and attachment. Our robust in situ forming ELP/BG composite hydrogels will be useful as injectable scaffolds for delivering cell and drug molecules to promote soft tissue regeneration in the future.