Composition and Systemic Immune Activity of the Polysaccharides from an Herbal Tea (Lycopus lucidus Turcz)

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• 作者：Xingbin Yang ; You Lv ; Lingmin Tian ; Yan Zhao
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2010
• 出版时间：May 26, 2010
• 年：2010
• 卷：58
• 期：10
• 页码：6075-6080
• 全文大小：775K
• 年卷期：v.58,no.10(May 26, 2010)
• ISSN：1520-5118

文摘

This study was undertaken to characterize the water-soluble polysaccharides isolated from an herbal tea, the leaves of L. lucidus Turcz. HPLC analysis showed that L. lucidus polysaccharides (LLPs) were mainly composed of galactose (50.1 mol %), followed by galacturonic acid (14.2 mol %), accounting for 64.3 mol % of all quantitative nine monosaccharides. Furthermore, we evaluated the systemic immunological efficacy of LLPs in mice. Mice were intragastrically administered once daily with low-dose (50 mg/kg), intermediate-dose (100 mg/kg), and high-dose (300 mg/kg) of LLPs, respectively, for 30 consecutive days. In comparison with vehicle, LLPs significantly enhanced the plaque-forming cells (PFCs), and serum hemolysin level, and delayed-type hypersensitivity (DTH) in response to sheep red blood cells (SRBC) in a dose-dependent manner (p < 0.01). In LLPs-treated mice, phagocytosis capacity and concanavalin A-induced spleenocyte proliferation were remarkably increased (p < 0.05). The intermediate- and high-dose of LLPs also caused a significant increase in the indices of thymus and spleen organs of mice (p < 0.05). This suggests that the polysaccharides derived from the tea leaves of L. lucidus improves the immune system and might be regarded as a biological response modifier.