Combinatorial Solid-Phase Synthesis of 4,6-Diaryl and 4-Aryl, 6-Alkyl-1,3,5-triazines and Their Application to Efficient Biofuel Production

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• 作者：Jaoon Y. H. Kim ; Jae Wook Lee ; Woo Sirl Lee ; Hyung-Ho Ha ; Marc Vendrell ; Jacqueline T. Bork ; Youngsook Lee ; Young-Tae Chang
• 刊名：ACS Combinatorial Science
• 出版年：2012
• 出版时间：July 9, 2012
• 年：2012
• 卷：14
• 期：7
• 页码：395-398
• 全文大小：238K
• 年卷期：v.14,no.7(July 9, 2012)
• ISSN：2156-8944

文摘

Herein we report the solid-phase synthesis of a combinatorial aryl, alkyl-triazine library and its application to biofuel production. The combination of Grignard reactions and solid supported Suzuki coupling reactions afforded unique 120 triazine compounds with high purities and minimum purification steps. Through an unbiased phenotypic screening for improved biofuel generation in oleaginous yeast, we found one diaryl triazine derivative (E4) which increased the biolipid production up to 86%.

Keywords:

hors" href="http://pubs.acs.org/action/doSearch?action=search&searchText=triazines&qsSearchArea=searchText">triazines; hors" href="http://pubs.acs.org/action/doSearch?action=search&searchText=Grignard+reaction&qsSearchArea=searchText">Grignard reaction; hors" href="http://pubs.acs.org/action/doSearch?action=search&searchText=Suzuki+coupling&qsSearchArea=searchText">Suzuki coupling; hors" href="http://pubs.acs.org/action/doSearch?action=search&searchText=biolipids&qsSearchArea=searchText">biolipids; hors" href="http://pubs.acs.org/action/doSearch?action=search&searchText=high%5C-throughput+screening&qsSearchArea=searchText">high-throughput screening; hors" href="http://pubs.acs.org/action/doSearch?action=search&searchText=chemical+genetics&qsSearchArea=searchText">chemical genetics