Novel Gold(I) 7-Azacoumarin Complex: Synthesis, Structure, Optical Properties, and Cytotoxic Effects

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• 作者：José ; S. Casas ; Eduardo E. Castellano ; Mar&iacute ; a D. Couce ; Olga Crespo ; Javier Ellena ; Antonio Laguna ; Agust&iacute ; n Sá ; nchez ; José ; Sordo ; Carmen Taboada
• 刊名：Inorganic Chemistry
• 出版年：2007
• 出版时间：August 6, 2007
• 年：2007
• 卷：46
• 期：16
• 页码：6236 - 6238
• 全文大小：65K
• 年卷期：v.46,no.16(August 6, 2007)
• ISSN：1520-510X

文摘

A mixture of pyridoxalrhodanine, triethylphosphinegold(I) chloride,and sodium methoxide in methanol unexpectedly afforded theazacoumarin complex [Au(TS)(PEt₃)] [HTS = 5-(hydroxymethyl)-8-methyl-3-thiol-7-azacoumarin], which was characterized by X-raydiffractometry. Its crystals consist of independent molecules in whichthe metal atom is bound to the azacoumarin [Au-S = 2.9458(18)Å] and the phosphine [Au-P = 2.262(2) Å] in an almost lineararrangement [P1-Au1-S1 = 176.93(7)]. The complex showedbetter in vitro antitumor activity than cisplatin against the cisplatin-resistant cell line A2780cis.