An Efficient Method for the Synthesis of Nitropiperidones

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• 作者：José ; Luis Garc&iacute ; a Ruano ; Teresa de Haro ; Rajinder Singh ; M. Belé ; n Cid
• 刊名：Journal of Organic Chemistry
• 出版年：2008
• 出版时间：February 1, 2008
• 年：2008
• 卷：73
• 期：3
• 页码：1150 - 1153
• 全文大小：78K
• 年卷期：v.73,no.3(February 1, 2008)
• ISSN：1520-6904

文摘

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A three step efficient strategy for the synthesis of substituted5-nitropiperidones in high de, employing Michael additionof N-p-tolylsulfinyl fchars/beta2.gif" BORDER=0 ALIGN="middle">-nitroamines to fchars/alpha.gif" BORDER=0>,fchars/beta2.gif" BORDER=0 ALIGN="middle">-unsaturated esters,hydrolysis of the sulfinyl group, and cyclization of theresulting free amines, has been developed. A very simpleexperimental procedure involving mild conditions and onlyone chromatographic purification are the main features ofthe process.